Lithium Orotate Side Effects

Lithium orotate is not a medication like lithium carbonate. Instead, it is marketed as a dietary supplement with a number of possible benefits including: mood alteration, boosting the immune system, and migraine relief. In an NCBI study, it was even used as a somewhat successful alcohol dependency treatment. However, it is not approved by the FDA to treat any specific medical conditions. In addition, the supplement does commonly cause a number of side effects when taken regularly.

Loss of Appetite

Lithium Orotate

A lack of appetite is associated with Lithium Orotate.

Lithium orotate has been known to cause appetite loss in some cases, such as the NCBI study. Although it was described as a “minor” side effect, it can be potentially dangerous to take any kind of substance that changes your appetite. This can lead to weight loss and, in some cases, malnourishment. It is important to discuss this possibility with your doctor before you begin taking the supplement.


Some individuals decide to take this supplement because they believe it will have positive effects on their mood. It has even been touted as an over-the-counter remedy that helps with depression. However, the substance can also cause apathy in some users.

The prescription drug lithium is sold under the brand name Lithobid (NLM). While it is FDA-approved to treat mood disorders, unlike lithium orotate, Lithobid has been known to cause depressive moods, especially while the drug is still being introduced to a person’s system. Therefore, it is important to remember that apathetic and depressive side effects may still occur when taking lithium orotate.


Lithobid commonly causes dizziness when taken in higher doses. However, lithium orotate can cause considerably strong effects for a dietary supplement, and some individuals complain of dizziness, faintness, and fatigue. It is important to discontinue your use of the supplement if you begin to experience these side effects.

Gastrointestinal Problems

Nausea and vomiting are common side effects caused by lithium in any of its forms, while constipation may also occur. The substance can often cause a number of other gastrointestinal problems which can include

  • Indigestion
  • Gas
  • Stomach pain and discomfort
  • Bloating

This can help lead to the issues of appetite loss. While it can be a mild side effect, feeling that your stomach is constantly upset or that you are experiencing a number of GI problems may mean that it is time to stop taking lithium orotate.

Dry Mouth

Lithobid commonly causes dry mouth, thirst, and other issues. These can be mild or severe depending on the individual, and use of the drug should be discontinued if a person experiences severe dry mouth, thirst, or frequent urination (NLM). Lithium orotate is not as strong as Lithobid, but it is common to experience some dry mouth as a result of using the drug.

The side effects of lithium orotate are somewhat unpredictable, as the substance is not approved by the FDA to treat any medical condition, nor have its effects been widely studied. You should consult with your doctor before deciding to take any type of supplement, as there could be certain side effects you may be more prone to experience given your medical history. The side effects of lithium orotate can often be mild but, depending on the situation, may also become severe.